Doses studied
Ipamorelin dosage, as the studies administered it — not as a recommendation.
Human IV ranges, rodent subcutaneous regimens, the ~2-hour half-life, and the honest fact that the popular stack protocols rest on no controlled human data.
Read this first
This page reports ipamorelin dosage the way the published studies reported it — which doses were given, to which species, by which route, for how long. It is not a protocol and contains no recommendation. There is a specific reason for that beyond house rules: no controlled human study has ever established a safe or effective ipamorelin dose for any wellness use. The human doses on record were given by IV in a hospital research setting [2][3]; the rest are animal doses [4][5].
The popular "how much CJC-1295 ipamorelin should I take" question has no evidence-based answer, because the combination has never been dose-finding-tested in a controlled human trial [13][17]. Everything below is framed as what was administered in a study, in the third person, with no instruction for any reader. The numbers are here for understanding the pharmacology, not for use.
The doses that appear in the literature
Human (IV, research and trial settings). The pharmacokinetic study used five 15-minute IV infusions of 4.21, 14.02, 42.13, 84.27, and 140.45 nmol/kg as single doses [2]. The Phase 2 ileus trial used 0.03 mg/kg IV twice daily for up to 7 days [3]. Both were intravenous and clinician-administered; neither supports any self-administration regimen.
Rat (subcutaneous and IV). The bone-growth study used 18, 90, and 450 micrograms/day subcutaneously, split three times daily for 15 days [4]. A bone-mineral study used 0.5 mg/kg/day by continuous subcutaneous minipump for 12 weeks. A postoperative-ileus model used 0.1–1 mg/kg IV repeated four times daily.
Ferret (2024). The cisplatin weight-loss study used 1–3 mg/kg intraperitoneally [5].
Community stack protocols. Forum and clinic regimens pair ipamorelin with CJC-1295 subcutaneously. These have no peer-reviewed human dosing basis and are described here only as anecdotal practice, not as recommendations.
Half-life and pharmacokinetics
Ipamorelin's terminal half-life in healthy human volunteers is approximately 2 hours (IV), with clearance of 0.078 L/h/kg and a steady-state volume of distribution of 0.22 L/kg [2]. The growth-hormone response is a single discrete pulse peaking around 40 minutes (0.67 h) after dosing [2]. In rats, plasma clearance is roughly 5-fold lower than GHRP-6, and intranasal bioavailability is about 20%. The practical reading: ipamorelin produces a brief, sharp growth-hormone pulse and then clears quickly — the pharmacology of a short-acting secretagogue, which is precisely why community protocols pair it with a long-acting GHRH analog whose action persists across days [13].
How much cjc-1295 ipamorelin should i take
There is no evidence-based dose to report. No controlled human trial has performed dose-finding for the CJC-1295 + ipamorelin combination, so any specific microgram figure circulating online is community convention, not a studied dose [13][17]. What the literature does support is the single-agent pharmacology: ipamorelin's human exposure was studied only by IV [2][3], and CJC-1295's published doses were 30–60 micrograms/kg subcutaneously in pharmacokinetic studies [13]. Combining them into a self-administered "protocol" extrapolates well beyond anything tested. This site does not provide a dose, a titration schedule, or an administration instruction for the combination.
How to reconstitute cjc-1295 ipamorelin 5mg
Reconstitution is a handling question, and the answer here is general and non-prescriptive. Ipamorelin is supplied as a lyophilized (freeze-dried) powder, as either the free base or the acetate salt, and is reconstituted with bacteriostatic water for research handling. As a peptide it degrades with heat and repeated freeze-thaw, so reconstituted solution is typically kept refrigerated. These are general peptide-handling observations drawn from the research-supply literature — not a clinical preparation instruction, not a dosing volume, and not guidance for human use. The specific milligram-to-milliliter math that determines a dose is exactly the step this site does not provide, because a finished combination product has no validated human dosing standard.